【血宫】

★和四代一样依旧是101关。每10关有一次奖励，每5分钟+5%红魂，100分钟后x2。Death Scissors作为某些关卡的奖励怪物出现，如果在关卡列表中已有的话则算以正常状态出现。

关卡设置：

• Human:
• Stage 1: Empusa x4
• Stage 2: Green Empusa x4
• Stage 3: Pyrobat x2
• Stage 4: Caina x3
• Stage 5: Death Scissors x1
•  
• Devil Hunter:
• Stage 6: Scudo x2
• Stage 7: Baphomet x2
• Stage 8: Riot x3
• Stage 9: Qliphot tentacles x2
• Stage 10 (5k bonus): Empusa x10; Queen x1; Green x4
• Stage 11: Antenora x3
• Stage 12: Chaos x2
• Stage 13: Proto x1
• Stage 14: Lusachia x1
• Stage 15: Behemoth x1
• Stage 16: Hellbat x1
• Stage 17: Nobody x2
• Stage 18: Fury x1
• Stage 19: Empusa x4; Red Empusa x1
•  
• Son of Sparda:
• Stage 20 (50k bonus): Goliath
•  
• Devil Hunter:
• Stage 21: Empusa x3; Green x2
• Stage 22: Caina x2; Antenora x2
• Stage 23: Pyrobat x8; Hellbat x1
• Stage 24: Lusachia x1; Baphomet x2
• Stage 25: Fury x1; Riot x2
• Stage 26: Enraged Queen x1; Green x2
• Stage 27: Proto x1; Scudo x2
• Stage 28: Riot x1; Chaos x2
• Stage 29: Qliphot Tentacle x3
• Stage 30 (10k bonus): 1st wave: Caina x9/ 2nd wave: Antenorax6; Judeca x2
•  
• Son of Sparda:
• Stage 31: Pyrobat x3
• Stage 32: 1st wave: Hellbat x1/ 2nd wave: Empusa x5
• Stage 33: Death Scissors x2; delayed Nobody x1
• Stage 34: Pyrobat x3; Red Empusa x1
• Stage 35: Hellbat x3; slight delay Hellbat x2
• Stage 36: Caina x1; Green Empusa x2
• Stage 37: Behemoth x1; slight delay Death Scissors x3
• Stage 38: Qliphot Tentacle x4
• Stage 39: 1st wave: Pyrobat x3; 2nd wave: Hellbat x2; 3rd Wave: Death Scissors x2
• Stage 40 (60k bonus): Artemis
• Stage 41 (arena change): Baphomet x1; Empusa x4
• Stage 42: Scudo x2; slight delay Empusa x6
• Stage 43: Judeca x1; delayed Green Empusa x3
• Stage 44: Chaos x2; slight delay Empusa Queen x1
• Stage 45: Empusa x106; Fury x1
• Stage 46: Nobody x3; Green Empusa x3
• Stage 47: Antenora x3; Empusa Queen x1
• Stage 48: Empusa x5; Behemoth x1
• Stage 49: Riot x1; Green Empusa x2
• Stage 50 (20k bonus): Enraged Empusa Queen x3
• Stage 51: Red Empusa x2
• Stage 52: Caina x2; Pyrobat x1
• Stage 53: Death Scissors x2 (normal spawn); Lusachia x1
• Stage 54: 1st wave: Qliphot Tentacle x1/ Wave 2: Behemoth x3
• Stage 55: Proto x1; Caina x3
• Stage 56: Scudo x1; Baphomet x2
• Stage 57: Proto x2
• Stage 58: Scudo x2; Death Scissors x1 (normal spawn)
• Stage 59: Proto x1; Qliphot Tentacle x6
• Stage 60 (80k bonus): Caveliere
• Stage 61: Riot x4
• Stage 62: Riot x2; Hellbat x1
• Stage 63: Chaos x1; slight delay Baphomet x2
• Stage 64: Antenora x2; Fury x1
• Stage 65: Behemoth x1; Chaos x2
• Stage 66: Qliphot Tentacle x6; Fury x1
• Stage 67: Empusa Queen x1; Riot x3
• Stage 68: Chaos x2; Nobody x1
• Stage 69: Chaos x1; Green Empusa x2
• Stage 70 (30k bonus): Fury x3
• Stage 71: Caina x2; Green Empusa x3
• Stage 72: Antenora x3; Pyrobat x2
• Stage 73: Empusa x8; Judeca x1
• Stage 74: Caina x7; delayed Lusachia x1
• Stage 75: Antenora x6; Behemoth x1
• Stage 76: Judeca x1; Nobody x2; Caina x1 and Antenora x1 summoned by Judeca
• Stage 77: Death Scissors x2 (normal spawn); Caina x1
• Stage 78: Antenora x1; Baphomet x2
• Stage 79: 1st wave: Proto x1; Judeca x2/ 2nd wave: Qliphot Tentacle x4
• Stage 80 (90k bonus): Malphas
•  
• Dante Must Die:
• Stage 81 (arena change): Empusa x10
• Stage 82: Antenora x4
• Stage 83: 1st wave: Riot x3; 2nd wave: Chaos x2
• Stage 84: Pyrobat x3; Green Empusa x4; delayed Hellbat x1
• Stage 85: Nobody x1; Behemoth x1; Empusa Queen x1
• Stage 86: Caina x2; Green Empusa x1
• Stage 87: Proto x1; Riot x2
• Stage 88: Fury x2
• Stage 89: Qliphot Tentacle x10
• Stage 90 (100k bonus): King Cerberus
• Stage 91: Red Empusa x3
• Stage 92: Baphomet x2; Caina x10
• Stage 93: Death Scissors x1 (normal spawn); very small delay Death Scissors x2; very small delay Death Scissors x2
• Stage 94: 1st wave: Scudo x1; delayed Lusachia x2/ 2nd wave: Qliphot Tentacle x3
• Stage 95: Empusa x1; Scudo x1; Caina x1; Pyrobat x1; spawn-on-kill Riot x1; spawn-on-kill Death Scissors x1
• Stage 96: Chaos x1; Antenora x1; Baphomet x1; spawn-on-kill Nobody x1; spawn-on-kill Hellbat x1; Pyrobat x1
• Stage 97: 1st wave: Proto x1; slight delay Judeca; spawn-on-kill Behemoth x1; spawn-on-kill Empusa Queen x1; spawn-on-kill Lusachia x1; spawn-on-kill Fury x1/ 2nd wave: Qliphot Tentacle x3
• Stage 98: Urizen 1 (ends on crystal break)
• Stage 99: Urizen 2
• Stage 100 (110k bonus): Urizen 3 (drops green orbs)
• Stage 101: Vergil
• All stages bonus: 300k